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Predictors and outcomes of linezolid-resistant vancomycin-resistant Enterococcus: a case-case-control study
Kayoko Hayakawa1, Dror Marchaim, Jason M Pogue
1Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA. fastriver7k@yahoo.co.jp
American Journal of Infection Control
|December 4, 2012
Summary
This study identified key risk factors for linezolid-resistant vancomycin-resistant Enterococcus (VRE) infections. Understanding these predictors helps in managing VRE and optimizing antibiotic use.
Area of Science:
- Infectious Diseases
- Antimicrobial Resistance
- Clinical Microbiology
Background:
- Vancomycin-resistant Enterococcus (VRE) poses a significant treatment challenge.
- Linezolid is a crucial antibiotic for VRE infections.
- Emergence of linezolid resistance in VRE necessitates understanding its drivers.
Purpose of the Study:
- To identify independent predictors for the isolation of linezolid-resistant VRE (LZD-R-VRE).
- To analyze clinical outcomes associated with linezolid resistance in VRE infections.
Main Methods:
- Retrospective analysis of VRE isolates.
- Identification of independent predictors for LZD-R-VRE isolation.
- Comparative analysis of outcomes between LZD-R-VRE and LZD-susceptible-VRE.
Main Results:
- Immunosuppression, prior surgery, and previous β-lactam antibiotic exposure were independent predictors for LZD-R-VRE.
- These factors did not predict isolation of linezolid-susceptible VRE.
- Prior linezolid exposure was not a predictor for LZD-R-VRE isolation.
Conclusions:
- Specific patient factors increase the risk of developing linezolid-resistant VRE infections.
- Targeted interventions for high-risk patients may mitigate the emergence of linezolid resistance.
- Further research is needed to elucidate mechanisms and refine treatment strategies.
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