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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...

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CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
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MicroRNAs in common human diseases.

Yu Li1, Kris V Kowdley

  • 1Benaroya Research Institute and Center for Liver Disease, Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA 98101, USA. yli@benaroyaresearch.org

Genomics, Proteomics & Bioinformatics
|December 4, 2012
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are short RNA molecules implicated in human diseases. Research advances suggest miRNAs could become future diagnostics and therapeutics for public health benefits.

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Area of Science:

  • Biomedical Research
  • Molecular Biology
  • Genomics

Background:

  • MicroRNAs (miRNAs) are short non-coding RNA molecules.
  • Over 1900 human miRNAs have been discovered.
  • Many miRNAs are linked to common human disorders.

Purpose of the Study:

  • To overview miRNA research progress in human diseases.
  • To explore the potential of miRNAs as diagnostics and therapeutics.

Main Methods:

  • High-throughput genomics
  • Bioinformatics
  • Traditional molecular biology techniques
  • Animal models

Main Results:

  • Significant progress in miRNA research related to human diseases.
  • Identification of numerous miRNAs implicated in various disorders.

Conclusions:

  • miRNA research is advancing from the lab to clinical applications.
  • miRNAs hold potential as the next generation of diagnostics and therapeutics for public health.