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Updated: May 16, 2026
10:33
Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
[Severe pseudouveitis associated with moxifloxacin therapy]
A Duncombe1, J Gueudry, N Massy
1Service d'ophtalmologie, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.
Journal Francais D'Ophtalmologie
|December 4, 2012
Summary
Systemic moxifloxacin, an antibiotic, may cause severe uveitis, a rare eye condition. This adverse effect, characterized by pigment dispersion and iris transillumination, requires prompt recognition by healthcare providers.
Area of Science:
- Ophthalmology
- Pharmacology
- Infectious Diseases
Background:
- Moxifloxacin is a fluoroquinolone antibiotic used for bacterial sinusitis and chronic bronchitis.
- Systemic use of moxifloxacin has been linked to potential severe ocular side effects.
Observation:
- A case report details a patient developing severe acute uveitis after moxifloxacin treatment.
- Symptoms included bilateral eye pain, pigment dispersion, and iris transillumination, complicated by ocular hypertension.
- Extensive testing ruled out other causes, including herpes viruses.
Findings:
- Drug-induced uveitis is uncommon, but fluoroquinolone use is a possible etiological factor.
- Moxifloxacin was suspected in 25 out of 40 reported cases of fluoroquinolone-associated uveitis.
- Iris transillumination and pigment dispersion are specific indicators of this moxifloxacin-related uveitis.
Implications:
- Ophthalmologists and prescribers should be aware of this potential moxifloxacin adverse effect.
- Early recognition and management are crucial for patients experiencing ocular symptoms post-moxifloxacin treatment.
- Reporting such cases aids in pharmacovigilance and understanding drug safety profiles.
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