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Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Inhibitors of Bacterial DNA Synthesis01:28

Inhibitors of Bacterial DNA Synthesis

Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These antibiotics are selectively...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Nephrotic Syndrome III : Nursing Management

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Related Experiment Video

Updated: May 16, 2026

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

[Severe pseudouveitis associated with moxifloxacin therapy].

A Duncombe1, J Gueudry, N Massy

  • 1Service d'ophtalmologie, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.

Journal Francais D'Ophtalmologie
|December 4, 2012
PubMed
Summary

Systemic moxifloxacin, an antibiotic, may cause severe uveitis, a rare eye condition. This adverse effect, characterized by pigment dispersion and iris transillumination, requires prompt recognition by healthcare providers.

Related Experiment Videos

Last Updated: May 16, 2026

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Infectious Diseases

Background:

  • Moxifloxacin is a fluoroquinolone antibiotic used for bacterial sinusitis and chronic bronchitis.
  • Systemic use of moxifloxacin has been linked to potential severe ocular side effects.

Observation:

  • A case report details a patient developing severe acute uveitis after moxifloxacin treatment.
  • Symptoms included bilateral eye pain, pigment dispersion, and iris transillumination, complicated by ocular hypertension.
  • Extensive testing ruled out other causes, including herpes viruses.

Findings:

  • Drug-induced uveitis is uncommon, but fluoroquinolone use is a possible etiological factor.
  • Moxifloxacin was suspected in 25 out of 40 reported cases of fluoroquinolone-associated uveitis.
  • Iris transillumination and pigment dispersion are specific indicators of this moxifloxacin-related uveitis.

Implications:

  • Ophthalmologists and prescribers should be aware of this potential moxifloxacin adverse effect.
  • Early recognition and management are crucial for patients experiencing ocular symptoms post-moxifloxacin treatment.
  • Reporting such cases aids in pharmacovigilance and understanding drug safety profiles.