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Updated: May 16, 2026

Assessment of Boron Doped Diamond Electrode Quality and Application to In Situ Modification of Local pH by Water Electrolysis
Published on: January 6, 2016
Square-wave voltammetric determination of bezafibrate in pharmaceutical formulations using a cathodically pretreated
Jorge Armando Ardila1, Elen Romão Sartori, Romeu C Rocha-Filho
1Departamento de Química, Universidade Federal de São Carlos, C.P. 676, São Carlos-SP 13560-970, Brazil.
Abstract:
The determination of bezafibrate (BZF) using square-wave voltammetry (SWV) and a cathodically pretreated boron-doped diamond electrode is proposed. Cyclic voltammetry results showed one irreversible oxidation peak for BZF at 1.20 V (vs. Ag/AgCl (3.0 mol L(-1) KCl)) in a 0.04 mol L(-1) Britton-Robinson (BR) buffer solution (pH 2.0). Under optimized SWV conditions, a linear analytical curve is obtained for the BZF concentration range 0.10-9.1 μmol L(-1) in the BR buffer solution (pH 2.0), with a detection limit of 0.098 μmol L(-1). The obtained recoveries range from 93.4 to 108%. The proposed novel method was successfully applied in the determination of the BZF content in several pharmaceutical formulations (tablets) and the results are in close agreement (at a 95% confidence level) with those obtained using a comparative spectrophotometric method.
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