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ADIPOQ gene polymorphisms and cancer risk: a meta-analysis
Yuan Yang1, Fan Zhang, Rongjing Ding
1First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
This meta-analysis suggests two ADIPOQ gene polymorphisms, rs2241766 and rs1501299, may be linked to a reduced cancer risk. Further research is needed to confirm these findings on cancer genetics.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Inconsistent findings exist regarding ADIPOQ gene polymorphisms and cancer risk.
- Individual studies have limitations in assessing the association.
- A meta-analysis can provide a more precise overall effect estimate.
Purpose of the Study:
- To conduct a meta-analysis of studies investigating ADIPOQ gene polymorphisms and cancer risk.
- To provide a more precise overall effect estimate by pooling data from multiple studies.
- To identify specific ADIPOQ single nucleotide polymorphisms (SNPs) associated with cancer risk.
Main Methods:
- Searched PubMed and Embase for relevant studies published up to May 2012.
- Assessed the strength of the relationship using odds ratios (ORs).
- Included fifteen studies considering five SNPs, using fixed-effects or random-effects models.
Main Results:
- A significant association was found between SNP rs2241766 and reduced cancer risk in the recessive model (OR: 0.768).
- SNP rs1501299 showed a significant association with reduced cancer risk in allele contrast (OR: 0.141) and dominant model (OR: 0.904).
- No significant association was found for SNPs rs266729, rs822395, or rs822396, even after adjustment.
Conclusions:
- Two ADIPOQ gene polymorphisms, SNP rs2241766 and SNP rs1501299, may be associated with a reduced risk of cancer.
- The strength of the observed associations is mild to moderate.
- Additional well-designed studies are required to confirm these findings and their clinical implications.
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