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Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Stress Prevention and Stress Management Techniques I01:26

Stress Prevention and Stress Management Techniques I

Stress prevention and management are crucial for maintaining well-being and building resilience. Techniques to manage stress include cultivating qualities like conscientiousness, a sense of personal control, and self-efficacy. Each of these traits significantly reduces stress and promotes healthier lifestyle choices and outcomes.
Conscientiousness
Conscientious individuals tend to be organized, responsible, and disciplined. They prioritize completing tasks and following structured routines,...

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Related Experiment Video

Updated: May 16, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Biomarkers, interventions and healthy ageing.

Almas Kenessary1, Zhaxybay Zhumadilov, Talgat Nurgozhin

  • 1Center for Life Sciences, Nazarbayev University, 53 Kabanbay batyr ave, Astana 010000, Kazakhstan.

New Biotechnology
|December 4, 2012
PubMed
Summary

Population ageing presents a significant healthcare challenge, marked by increased morbidity and reduced quality of life. Cross-species research reveals common ageing processes and genetic pathways, offering insights into interventions for extended healthy lives.

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Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
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Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

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Last Updated: May 16, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

Area of Science:

  • Gerontology and public health
  • Molecular biology and genetics

Background:

  • Population ageing is a primary global healthcare concern in the 21st century.
  • Ageing is associated with increased morbidity, reduced quality of life, and complex pathological impairments.
  • Historically, ageing was viewed as a collection of distinct disease mechanisms, not a unified process.

Purpose of the Study:

  • To explore the concept of ageing as a fundamental biological process.
  • To investigate common ageing mechanisms across different species.
  • To identify genetic pathways that regulate ageing and its associated pathologies.

Main Methods:

  • Comparative analysis of ageing processes across diverse species.
  • Genetic studies to identify pathways influencing ageing.
  • Investigation of mutant pathways affecting lifespan and healthspan.

Main Results:

  • Evidence suggests conserved ageing processes and genetic pathways exist across species.
  • Manipulation of identified genetic pathways can delay or accelerate ageing-related diseases.
  • Mutants in these pathways lead to extended healthy lifespans or progeria-like conditions.

Conclusions:

  • Ageing is a fundamental biological process with identifiable common mechanisms.
  • Understanding these conserved pathways offers potential for novel therapeutic interventions.
  • Cross-species research is crucial for advancing knowledge on ageing and developing strategies for healthier longevity.