Long-term running alleviates some behavioral and molecular abnormalities in Down syndrome mouse model Ts65Dn

Area of Science:

• Neuroscience
• Animal Models
• Exercise Physiology

Background:

• Down syndrome (DS) is associated with cognitive and motor deficits.
• Ts65Dn mice serve as a valuable genetic model for studying DS.
• The impact of sustained physical exercise on DS models is an area of active research.

Purpose of the Study:

• To investigate the effects of voluntary running on cognition and motor function in Ts65Dn mice.
• To examine how sustained running influences specific brain protein levels in this DS model.
• To determine if the timing of exercise initiation (early vs. adult) affects outcomes in Ts65Dn mice.

Main Methods:

• Ts65Dn and wild-type female mice were divided into running and sedentary groups.
• Mice had access to running wheels from weaning or adulthood for several months.
• Behavioral tests assessed cognition and motor performance; brain protein levels (SOD1, DYRK1A, MAP2, APP, synaptophysin) were analyzed.

Main Results:

• Voluntary running improved cognitive function and motor skills in Ts65Dn mice.
• Early running (from weaning) enhanced object memory more than adult-initiated running.
• Running altered brain protein levels, including reductions in APP and MAP2ab and increases in SOD1, particularly in the early-running group.

Conclusions:

• Sustained voluntary physical exercise benefits Ts65Dn mice, with earlier initiation showing more pronounced effects.
• Exercise programs may serve as an important adjunctive therapy for Down syndrome.
• These findings support the potential of physical activity in managing DS-related challenges.