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Related Experiment Video

Updated: May 16, 2026

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Published on: March 25, 2016

Brain interleukin-15 in neuroinflammation and behavior.

Weihong Pan¹, Xiaojun Wu, Yi He

¹Blood-Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. weihong.pan@pbrc.edu

Neuroscience and Biobehavioral Reviews

|December 4, 2012

Summary

Interleukin-15 (IL-15) signaling in the brain impacts neurobehavior and neurotransmitters. This cytokine may offer therapeutic potential for neuropsychiatric disorders by modulating mood, memory, and neuronal activity.

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Last Updated: May 16, 2026

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Published on: March 25, 2016

Area of Science:

Neuroscience
Immunology
Molecular Biology

Background:

Interleukin-15 (IL-15) is a cytokine with intracellular and secretory forms.
IL-15 and its receptors are present in the brain, with upregulated expression during neuroinflammation.
IL-15 signaling is implicated in cerebral function and neuropsychiatric behaviors.

Purpose of the Study:

To review the expression, regulation, and functions of IL-15 and its receptors in the brain.
To explore the role of IL-15 in neurobehavior, neurotransmission, and neuroplasticity.
To investigate the potential therapeutic applications of IL-15 in neuropsychiatric conditions.

Main Methods:

Review of existing literature on IL-15 in the central nervous system (CNS).
Analysis of studies involving IL-15, IL-15Rα, and IL2Rγ gene deletions in neurobehavioral models.
Examination of IL-15 treatment effects on neuronal activity and neurotransmitter systems.

Main Results:

IL-15 receptor upregulation in neuroinflammation suggests a significant role in brain function.
IL-15 deletion impacts neurobehavior and neurotransmitter levels, including GABA and serotonin.
Peripheral IL-15 can activate CNS pathways, influencing mood, memory, sleep, and thermoregulation.

Conclusions:

IL-15 plays a crucial role in modulating neurotransmission (GABA and serotonin) and neurobehavior.
Despite limited blood-brain barrier penetration, peripheral IL-15 affects widespread CNS regions.
IL-15 demonstrates potential as a therapeutic agent for preventing neuropsychiatric symptoms.