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Intraventricular antimicrobial therapy in postneurosurgical Gram-negative bacillary meningitis or ventriculitis: a

Jui-Hsing Wang1, Po-Chang Lin1, Chia-Hui Chou1

  • 1Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|December 4, 2012
PubMed
Abstract

Insights

Intraventricular antibiotic therapy offers a viable treatment for postneurosurgical Gram-negative bacillary meningitis (GNBM) or ventriculitis. This approach proved effective in refractory cases, achieving a 73.3% cure rate without significant adverse events.

Area of Science:

  • Infectious Diseases
  • Neurosurgery
  • Pharmacology

Background:

  • Postneurosurgical Gram-negative bacillary meningitis (GNBM) or ventriculitis presents a significant clinical challenge.
  • Current treatment effectiveness is debated, with concerns regarding adverse drug effects.

Purpose of the Study:

  • To evaluate the efficacy and safety of intraventricular (IVT) antibiotic therapy for postneurosurgical GNBM or ventriculitis.
  • To assess outcomes in patients receiving sequential intravenous and IVT antibiotic treatment.

Main Methods:

  • Retrospective analysis of demographic data, treatment strategies, and clinical outcomes.
  • Collected data from 109 patients with 127 episodes of postneurosurgical GNBM or ventriculitis from 2003 to 2011.

Main Results:

  • Fifteen episodes were treated with sequential intravenous and IVT therapy; others received intravenous antibiotics alone.
  • The cure rate for IVT therapy was 73.3%, with CSF sterilization occurring in an average of 6.6 days.
  • No seizures or chemical ventriculitis were observed during IVT therapy.

Conclusions:

  • Intraventricular antibiotic therapy is a beneficial option for treating postneurosurgical GNBM or ventriculitis.
  • This therapy is particularly useful for patients with treatment-refractory infections.
Keywords:
Gram-negative bacilliIntraventricularMeningitisPostneurosurgicalVentriculitis

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