Related Experiment Video
Updated: May 16, 2026

Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia
Published on: September 12, 2020
Brain-derived neurotrophic factor Val66Met polymorphism is not associated with primary dystonia in a Chinese
Lingyan Ma1, Yi Chen, Lin Wang
1Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 1# Shuaifuyuan, Wangfujing Street, Beijing 100075, People's Republic of China.
Background:
Brain-derived neurotrophic factor (BDNF) is a modulator of synaptic and neural plasticity. Considering the association between dystonia and abnormal sensorimotor cortex plasticity, BDNF may be a candidate gene that confers susceptibility to dystonia. However, the association between Val66Met polymorphism of BDNF gene and primary dystonia is controversial.
Methods:
A case-control study was performed to evaluate the association between Val66Met polymorphism in the BDNF gene and primary dystonia in a cohort of 252 Chinese patients and in 214 age- and gender-matched healthy control subjects.
Results:
No association was identified between Val66Met polymorphism and primary dystonia or cervical dystonia (P=0.309 and P=0.803 respectively). In a subsequent subgroup analysis, there was also no difference in the distribution for age of onset.
Conclusion:
Our findings do not support that BDNF Val66Met polymorphism contributes to the risk of primary dystonia.
Related Concept Videos
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
The binding of dantrolene to the RYR1...
Alterations in Muscle Tone ll
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...

