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Related Concept Videos

Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
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For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
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Overview
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Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

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Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as conformers.

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Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
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Steering supramolecular patterns by nucleobase-terminated molecules.

Cai Shen1, Jacob R Cramer, Mikkel F Jacobsen

  • 1Interdisciplinary Nanoscience Center, Aarhus University, Denmark.

Chemical Communications (Cambridge, England)
|December 4, 2012
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Summary

Researchers studied how nucleobase-terminated molecular rods form patterns on graphite surfaces. Scanning tunneling microscopy revealed the self-assembly and supramolecular structures created by these molecules.

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Area of Science:

  • Materials Science
  • Surface Chemistry
  • Nanotechnology

Background:

  • Nucleobase-terminated molecular rods are building blocks for self-assembly.
  • Understanding molecular adsorption on surfaces is crucial for nanotechnology.
  • Graphite is a common substrate for surface science studies.

Purpose of the Study:

  • To investigate the supramolecular patterns formed by nucleobase-terminated molecular rods.
  • To explore the adsorption behavior of these molecules on a graphite surface.
  • To analyze the self-assembly mechanisms at the nanoscale.

Main Methods:

  • Scanning tunneling microscopy (STM) was employed to visualize the molecular arrangements.
  • Adsorption from a liquid phase onto a highly oriented pyrolytic graphite (HOPG) substrate was performed.
  • Analysis of the resulting patterns to understand intermolecular interactions.

Main Results:

  • Ordered supramolecular structures and patterns were observed.
  • The nucleobase termination influenced the self-assembly and pattern formation.
  • Specific adsorption configurations were identified on the graphite surface.

Conclusions:

  • Nucleobase-terminated molecular rods can form predictable supramolecular patterns on graphite.
  • The study provides insights into the design principles for molecular self-assembly.
  • This work contributes to the field of surface-mediated molecular organization.