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Action of retinoids during transformation of 10T1/2 cells
M Przybyszewska1, P Janik, J Miłoszewska
1Department of Tumor Biology, M. Skłodowska-Curie Institute of Oncology, Warsaw, Poland.
Neoplasma
|January 1, 1990
Abstract:
The effect of three retinoids, 13-cis-retinoic acid, arotinoid ethyl sulfone and retinal acetate, on methylcholanthrene (MCA) induced transformation of 10T1/2 cells was studied. It appears that 13-cis-retinoic acid and arotinoid ethyl sulfone prevent transformation in a direct way at the last stage of carcinogenesis. Retinal acetate, however, requires cell-to-cell contacts to inhibit the transformation of 10T1/2 cells.