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Related Experiment Video

Updated: May 16, 2026

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

Integrated-optics-based swept-source optical coherence tomography.

V Duc Nguyen¹, N Weiss, W Beeker

¹Biomedical Engineering & Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. d.v.nguyen@amc.uva.nl

|December 4, 2012

Summary

This summary is machine-generated.

We developed a compact integrated-optics swept-source optical coherence tomography (SS-OCT) system using TriPleX technology. This novel SS-OCT system achieves high resolution and sensitivity for detailed tissue imaging.

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Published on: October 2, 2021

Area of Science:

Photonics and Optical Engineering
Biomedical Imaging Technology
Integrated Optics

Background:

Optical Coherence Tomography (OCT) is a powerful non-invasive imaging modality.
Existing SS-OCT systems can be bulky and complex.
Advancements in integrated photonics offer miniaturization potential for OCT systems.

Purpose of the Study:

To design, fabricate, and characterize a compact SS-OCT system on a chip.
To leverage TriPleX technology for integrated interferometric depth ranging and detection.
To evaluate the performance of the integrated SS-OCT system for biomedical imaging applications.

Main Methods:

Fabrication of an integrated-optics chip in TriPleX technology with dimensions 0.4 cm × 1.8 cm.
Coupling an external 1300 nm swept source to the chip for OCT measurements.
Characterization of lateral resolution (21±1 μm), sensitivity (-80 dB), imaging depth (5.09 mm), and axial resolution (12.7±0.5 μm).
Demonstration of cross-sectional OCT imaging on a multilayered tissue phantom.

Main Results:

Successful design and fabrication of a miniaturized SS-OCT system on a single chip.
Achieved high lateral resolution of 21±1 μm and axial resolution of 12.7±0.5 μm.
Demonstrated excellent sensitivity of -80 dB and imaging depth up to 5.09 mm.
Validated the system's capability for cross-sectional imaging of tissue phantoms.

Conclusions:

The integrated-optics-based SS-OCT system in TriPleX technology represents a significant miniaturization of OCT devices.
The system exhibits high performance metrics suitable for various biomedical imaging applications.
This technology paves the way for more portable and accessible OCT imaging solutions.