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Neuronal migration anomalies causing extensive ventricular indentation.

K Yasumori1, K Hasuo, S Nagata

  • 1Department of Radiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Neurosurgery
|March 1, 1990
PubMed
Summary
This summary is machine-generated.

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Unusually large cortical heterotopia, a brain anomaly, can present with fused-lip schizencephaly. Radiologic findings mimic normal gray matter but indicate abnormal brain development, aiding in differential diagnosis.

Area of Science:

  • Neurology
  • Radiology
  • Developmental Neuroscience

Background:

  • Neuronal migration disorders are a group of brain anomalies.
  • Cortical heterotopia is the most common type of neuronal migration disorder.
  • This report focuses on rare, large cortical heterotopia cases.

Observation:

  • Two adult cases of unusually large cortical heterotopia associated with fused-lip schizencephaly were analyzed.
  • The lesions caused significant ventricular indentation.
  • Radiological findings included density on CT and signal intensity similar to normal gray matter on MRI.

Findings:

  • No perifocal edema, contrast enhancement, or calcification was observed.
  • Associated findings included ipsilateral cerebral hemisphere volume reduction, adjacent microgyri, and deep fissures with blood vessels.

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  • These features suggest abnormal brain development.

    • Implications:

    • Understanding these radiological features is crucial for accurate diagnosis.
    • Differentiating these developmental anomalies from true intracerebral neoplasms is essential.
    • This knowledge aids in the diagnostic process for complex brain malformations.