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Insulin-like growth factor binding protein-3 in preterm infants with retinopathy of prematurity

Manizheh Mostafa Gharehbaghi1, Ali Peirovifar, Karim Sadeghi

  • 1Women's Reproductive Health Research Center, Department of Pediatrics and Neonatology, Tabriz University of Medical Sciences, Tabriz, Iran.

Indian Journal of Ophthalmology
|December 4, 2012
PubMed

Insights

Lower levels of insulin-like growth factor binding protein -3 (IGFBP-3) are linked to retinopathy of prematurity (ROP) in premature infants. This suggests IGFBP-3 deficiency may play a role in the development of ROP.

Area of Science:

  • Neonatology
  • Ophthalmology
  • Endocrinology

Background:

  • Retinopathy of prematurity (ROP) is a leading cause of vision loss in premature infants.
  • Understanding the pathogenesis of ROP is crucial for developing effective interventions.

Purpose of the Study:

  • To investigate the association between insulin-like growth factor binding protein -3 (IGFBP-3) and proliferative ROP.
  • To explore the potential role of IGFBP-3 in the disease's development in premature infants.

Main Methods:

  • A case-control study involving 71 preterm infants (≤32 weeks gestation).
  • 41 infants without ROP (control group) and 30 with severe ROP (case group).
  • Blood samples analyzed for IGFBP-3 levels using ELISA 6-8 weeks after birth.

Main Results:

  • Infants with proliferative ROP had significantly lower IGFBP-3 blood levels compared to controls (P=0.009).
  • Lower Apgar scores were observed in the ROP group.
  • Plasma IGFBP-3 levels showed 65.9% sensitivity and 66.7% specificity for vasoproliferative ROP.

Conclusions:

  • Significantly lower IGFBP-3 blood levels were found in premature infants with ROP.
  • IGFBP-3 deficiency is suspected to contribute to the pathogenesis of proliferative ROP.
Abstract

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