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Forty-five years of Marburg virus research

Kristina Brauburger1, Adam J Hume, Elke Mühlberger

  • 1Department of Microbiology, School of Medicine and National Emerging Infectious Diseases Laboratories Institute, Boston University, Boston, MA 02118, USA. brauburk@bu.edu

Viruses
|December 4, 2012
PubMed

Insights

The first Marburg virus hemorrhagic fever outbreak occurred in 1967. This article comprehensively reviews Marburg virus disease, covering its ecology, pathogenesis, and molecular biology.

Area of Science:

  • Virology
  • Infectious Diseases
  • Epidemiology

Background:

  • The first documented outbreak of filovirus hemorrhagic fever occurred in 1967 in Germany and Yugoslavia.
  • Marburg virus, identified as the causative agent, is recognized as a highly lethal human pathogen.
  • Understanding Marburg virus disease is critical due to its public health implications.

Purpose of the Study:

  • To provide a comprehensive overview of Marburg virus disease.
  • To consolidate current knowledge on Marburg virus from diverse scientific domains.
  • To serve as a foundational resource for researchers and clinicians.

Main Methods:

  • Literature review of scientific publications on Marburg virus.
  • Synthesis of data on Marburg virus ecology.
  • Compilation of information on pathogenesis and molecular biology.

Main Results:

  • Detailed examination of the 1967 outbreak and subsequent Marburg virus discoveries.
  • Exploration of the ecological factors influencing Marburg virus transmission.
  • Analysis of the molecular mechanisms underlying Marburg virus pathogenesis.

Conclusions:

  • Marburg virus disease remains a significant global health threat.
  • Continued research into Marburg virus ecology, pathogenesis, and molecular biology is essential.
  • A comprehensive understanding is key to developing effective control and treatment strategies.

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