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Related Concept Videos

Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
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Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
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The pathophysiology of pneumonia involves the following steps:

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In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
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Published on: February 20, 2020

Pathogenesis of Lassa fever.

Nadezhda E Yun1, David H Walker

  • 1Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA. neyun@utmb.edu

Viruses
|December 4, 2012
PubMed
Summary
This summary is machine-generated.

Lassa fever, caused by Lassa virus, affects over 100,000 people annually in West Africa. This review details Lassa virus biology and pathogenesis, highlighting the need for vaccines and treatments.

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Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment
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Published on: March 2, 2016

Area of Science:

  • Virology
  • Infectious Diseases
  • Pathogenesis

Background:

  • Lassa virus (LASV) is an Old World arenavirus responsible for Lassa fever, a significant public health concern in West Africa.
  • Lassa fever causes over 100,000 infections and substantial mortality (5-10%) among hospitalized patients annually.
  • There are currently no approved vaccines or specific therapeutics for Lassa fever.

Purpose of the Study:

  • To review the existing literature on the life cycle of Lassa virus.
  • To focus on the pathogenesis of Lassa fever in humans and relevant animal models.
  • To consolidate current knowledge to guide future research in diagnostics, vaccines, and therapeutics.

Main Methods:

  • Comprehensive literature review of published studies on Lassa virus.
  • Analysis of research focusing on viral replication and host-pathogen interactions.
  • Examination of data from human cases and animal models of Lassa fever.

Main Results:

  • The review synthesizes information on Lassa virus biology, including its replication cycle and mechanisms of immune evasion.
  • It highlights key aspects of Lassa fever pathogenesis in both human infections and experimental models.
  • Current understanding reveals complex interactions between Lassa virus and the host immune system.

Conclusions:

  • Enhanced understanding of Lassa virus biology and pathogenesis is crucial for combating Lassa fever.
  • Further research is essential to develop effective diagnostic tools, vaccines, and antiviral therapies.
  • Addressing knowledge gaps will facilitate the design of improved interventions against this devastating disease.