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Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

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Virus-induced aggregates in infected cells.

Adi Moshe¹, Rena Gorovits

¹Institute of Plant Sciences and Genetics in Agriculture and the Otto Warburg Minerva Center for Agricultural Biotechnology, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel. adisara.moshe@mail.huji.ac.il

|December 4, 2012

Summary

Viruses create cellular aggregates, often containing viral proteins, which aid replication and transport. These structures can protect viruses or be targeted by host defenses, with diverse roles in plant and animal cells.

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Area of Science:

Virology
Cell Biology
Plant Pathology

Background:

Viruses induce cellular remodeling, forming insoluble aggregates/inclusions with viral proteins.
Aggregate identification is a diagnostic tool for specific viral infections.
Viral aggregates exhibit diversity in location, size, content, and function.

Purpose of the Study:

To review the diversity of virus-induced aggregates in mammalian and plant cells.
To explore the poorly understood roles of aggregation in specific viruses, particularly plant viruses.
To discuss the functions of viral aggregates in replication, transport, and host-virus interactions.

Main Methods:

Literature review of studies on viral aggregates in mammalian and plant cells.
Analysis of the structural and functional diversity of viral inclusions.
Comparative examination of aggregate roles in different host organisms.

Main Results:

Viral aggregates serve as compartments for viral replication and protein complexes.
Aggregates facilitate viral translation and intra-/intercellular transport.
These structures can shield viral components from cellular degradation or be involved in host defense.

Conclusions:

Virus-induced aggregates are diverse structures with multifaceted roles in viral life cycles.
Understanding these aggregates is crucial for comprehending virus-host interactions and developing diagnostics.
Further research is needed to elucidate the specific functions of aggregates for individual viruses, especially in plants.