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CCK-8S inhibits L-dopa-induced dyskinesias in parkinsonian squirrel monkeys
S Boyce1, N M Rupniak, M Steventon
1Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK.
Neurology
|April 1, 1990
Abstract:
Systemic administration of CCK-8S (1 or 10 micrograms/kg IP) markedly inhibited L-dopa-induced dyskinesias in parkinsonian monkeys, but did not interfere with locomotor stimulation by L-dopa. CCK analogues may be useful antidyskinetic agents for improved control of Parkinson's disease.