Default distrust? An fMRI investigation of the neural development of trust and cooperation

The tendency to trust and to cooperate increases from adolescence to adulthood. This social development has been associated with improved mentalizing and age-related changes in brain function. Thus far, there is limited imaging data investigating these associations. We used two trust games with a trustworthy and an unfair partner to explore the brain mechanisms underlying trust and cooperation in subjects ranging from adolescence to mid-adulthood. Increasing age was associated with higher trust at the onset of social interactions, increased levels of trust during interactions with a trustworthy partner and a stronger decline in trust during interactions with an unfair partner. Our findings demonstrate a behavioural shift towards higher trust and an age-related increase in the sensitivity to others' negative social signals. Increased brain activation in mentalizing regions, i.e. temporo-parietal junction, posterior cingulate and precuneus, supported the behavioural change. Additionally, age was associated with reduced activation in the reward-related orbitofrontal cortex and caudate nucleus during interactions with a trustworthy partner, possibly reflecting stronger expectations of trustworthiness. During unfair interactions, age-related increases in anterior cingulate activation, an area implicated in conflict monitoring, may mirror the necessity to inhibit pro-social tendencies in the face of the partner's actual levels of cooperation.