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Updated: May 16, 2026
Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
Published on: June 21, 2016
Age-related alterations in cardiac geometry in formerly preeclamptic women and healthy parous controls: an
Chahinda Ghossein-Doha1, Sander M J van Kuijk, Marc E A Spaanderman
1Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands. c.ghossein@maastrichtuniversity.nl
Introduction:
Preeclamptic pregnancies induce concentric left ventricular hypertrophy instead of eccentric left ventricular hypertrophy as seen in healthy pregnancies. Although these differences persist for at least several months postpartum, the long-term fate of these changes is unknown.
Objective:
To explore the age-related changes in cardiovascular structure and function in formerly preeclamptic women relative to parous controls.
Methods:
A total of 20 formerly preeclamptic women and 8 parous controls underwent 2 echocardiograms at 1 and 14 years of postpartum. With the nonparametric Mann-Whitney U test and the Wilcoxon Signed Ranks test, we analyzed the between-group differences in cardiac structure and function at both time points and the time-related changes in these indices.
Results:
Left ventricular geometry and dimensions and systolic function were comparable in the 2 study groups at both time points. The age-related decline in E/A ratio and increase in intraventricular septum thickness were noted in both groups over time, without appreciable differences between groups.
Conclusion:
A history of preeclampsia does not affect the age-related cardiac remodeling over a period of 14 years.
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