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C J M Schölzel-Dorenbos

    Tijdschrift Voor Gerontologie En Geriatrie
    |December 4, 2012
    PubMed
    Summary

    Pharmacological treatments for Alzheimer's disease (AD) in the Netherlands, including cholinesterase inhibitors and NMDA antagonists, offer limited symptom relief. Effective clinical practice requires comprehensive knowledge of these drugs and dementia care.

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    Area of Science:

    • Neurology
    • Pharmacology
    • Geriatrics

    Background:

    • Alzheimer's disease (AD) significantly impacts the elderly population in the Netherlands, with an estimated 195,000 patients aged 65 and older.
    • Current pharmacological options for AD include cholinesterase inhibitors (rivastigmine, galantamine) and an NMDA antagonist (memantine).

    Purpose of the Study:

    • To evaluate the current clinical practice of pharmacological therapy for Alzheimer's disease in the Netherlands.
    • To discuss the advantages and disadvantages of pharmacotherapy in managing AD symptoms.

    Main Methods:

    • Review of current clinical practice regarding Alzheimer's disease pharmacotherapy in the Netherlands.
    • Case-based discussion of patient care involving licensed AD medications.
    • Analysis of the pros and cons of drug treatments for AD.

    Main Results:

    • Licensed drugs such as rivastigmine, galantamine, and memantine demonstrate limited efficacy in improving cognitive and other dementia-related symptoms in clinical practice.
    • Effective management necessitates a thorough understanding of available pharmacotherapies and non-pharmacological interventions.

    Conclusions:

    • Pharmacotherapy for Alzheimer's disease in the Netherlands provides modest benefits for symptom management.
    • Optimal patient care and caregiver support require extensive knowledge of AD medications, alternative treatments, and the disease itself.

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