Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cardiomyopathy IV: Restrictive Cardiomyopathy

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

Heart Failure II: Pathophysiology

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

Mitral Stenosis I: Introduction

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

Aortic Regurgitation III: Medical Management

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...

Mitral Regurgitation I: Introduction

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The distinctive characteristics of the micro-vasculature and immune cell infiltration in cystic pancreatic neuroendocrine tumors.

Journal of endocrinological investigation·2020

Same author

[A summary of China's 70 years of development in diagnosis and treatment targeting corneal diseases].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2020

Same author

[A special on epidemic prevention and control: ophthalmologic research and prevention of 2019 novel coronavirus based on ocular manifestations of viral diseases].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2020

Same author

Transmission of viral pathogens in a social network of university students: the eX-FLU study.

Epidemiology and infection·2020

Same author

Long noncoding RNA UCA1 promotes proliferation and metastasis of thyroid cancer cells by sponging miR-497-3p.

European review for medical and pharmacological sciences·2020

Same author

[Bronchiolar adenoma: a clinicopathological analysis of 15 cases].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2020

Search research articles

Related Experiment Video

Updated: May 16, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

The relationship between arterial wall stiffness and left ventricular dysfunction.

Y Hu¹, L Li, L Shen

¹Department of Geriatrics, Qilu Hospital of Shandong University, 107 Culture West Road, Jinan, 250012, China.

Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

|December 4, 2012

Summary

This summary is machine-generated.

Arterial stiffening is directly linked to left ventricular (LV) dysfunction in hypertensive patients. Increased arterial stiffness predicts worsening LV diastolic function, independent of common risk factors.

More Related Videos

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

Related Experiment Videos

Last Updated: May 16, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

Area of Science:

Cardiovascular Medicine
Hypertension Research
Echocardiography

Background:

Arterial wall stiffening is a known complication of hypertension.
Left ventricular (LV) dysfunction can develop in patients with long-standing hypertension.
The relationship between arterial stiffness and LV dysfunction requires further elucidation.

Purpose of the Study:

To investigate the association between left ventricular (LV) dysfunction and arterial wall stiffening.
To determine if arterial stiffness is an independent predictor of LV diastolic function.

Main Methods:

A cohort of 218 hypertensive patients over 45 years old was studied.
Left ventricular (LV) function was assessed using echocardiography (ECHO).
Arterial stiffness parameters, blood pressure, and metabolic markers were measured.

Main Results:

Stiffness parameter beta positively correlated with LV diastolic function (E/Em ratio).
LV end-diastolic diameter was associated with both E/Em ratio and stiffness parameter beta.
Multiple regression analysis identified stiffness parameter beta as an early indicator of E/Em ratio.

Conclusions:

LV dysfunction is directly related to arterial stiffening, irrespective of shared risk factors.
Arterial stiffness serves as an independent predictor of LV diastolic function.
The severity of arterial stiffness correlates with the severity of LV dysfunction.