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Effect of adding bone marrow to ceramic graft materials with different interconnectivities in lumbar arthrodesis :
Guillaume-A Odri1, Romain Revert, Cedric Deschamps
1Clinique Chirurgicale Orthopédique et Traumatologique, CHU Hôtel Dieu, 1 Place Alexis Ricordeau, 44093 Nantes Cedex 1, France. gaodri@yahoo.fr
Introduction:
Combining bone marrow (BM) with graft materials can stimulate bone healing. However, bone growth is not quantified in most studies, and the influence of the rate of interconnectivity of ceramics loaded with bone marrow has not yet been quantified. Here, a rabbit model of posterolateral intertransverse arthrodesis was used to quantify the effect of adding BM to partially (PIC) or totally (TIC) interconnected ceramics.
Materials And Methods:
A single lumbar level was grafted on two sides with TIC (n = 12) or PIC (n = 18). The ceramic was loaded with 1.5 ml of BM on one side (chosen at random). The fusion rate was assessed by manual palpation test. Bone formation was quantified on scanning electron microscopy images and by dual-energy X-ray absorptiometry.
Results:
At week 6, bone formation with TIC was twice as high as that with PIC. When BM was added, 35.1 and 87.8 % more bone formation was observed in the TIC and PIC, respectively. In ceramics loaded with BM, the bone mineral density was significantly higher than that in ceramics alone.
Conclusions:
Differences in interconnectivity within the family of biphasic ceramics should be taken into account when applying them clinically. BM increased bone formation regardless of the type of ceramic employed.
