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Obesity and abdominal aortic aneurysm.

O Stackelberg1, M Björck, O Sadr-Azodi

  • 1Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden. otto.stackelberg@ki.se

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Summary

Increased waist circumference, a measure of abdominal adiposity, is linked to a higher risk of abdominal aortic aneurysm (AAA). Total adiposity, measured by body mass index (BMI), showed no association with AAA risk.

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Area of Science:

  • Cardiovascular epidemiology
  • Vascular disease research
  • Obesity and health outcomes

Background:

  • The link between obesity and abdominal aortic aneurysm (AAA) remains unclear.
  • Investigating adiposity measures like waist circumference and body mass index (BMI) in relation to AAA risk is crucial.

Purpose of the Study:

  • To examine the association between abdominal adiposity (waist circumference) and total adiposity (BMI) and the risk of developing abdominal aortic aneurysm (AAA).

Main Methods:

  • Utilized data from the Swedish Mammography Cohort and Cohort of Swedish Men (63,655 participants aged 46-84).
  • Identified 597 incident AAA cases between 1998-2009 via registry linkage.
  • Employed Cox proportional hazards models to calculate relative risks (RRs).

Main Results:

  • Higher waist circumference correlated with a 30% increased AAA risk (RR 1.30).
  • AAA risk rose by 15% per 5-cm waist circumference increment up to thresholds of 100 cm (men) and 88 cm (women).
  • No significant association was found between body mass index (BMI) and AAA risk.

Conclusions:

  • Abdominal adiposity, specifically increased waist circumference, is associated with a higher risk of incident abdominal aortic aneurysm (AAA).
  • Total adiposity, as measured by BMI, was not linked to AAA risk.
  • Identified specific waist circumference thresholds (100 cm for men, 88 cm for women) associated with increased AAA risk.