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Related Concept Videos

Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

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Preparation of Frozen Non-Human Primate Fetal Islets for Combined Single Nuclei RNA-Sequencing and ATAC-Sequencing, and Bulk Metabolomics
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The non-human primate reference transcriptome resource (NHPRTR) for comparative functional genomics.

Lenore Pipes1, Sheng Li, Marjan Bozinoski

  • 1Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10065, USA.

Nucleic Acids Research
|December 4, 2012
PubMed
Summary
This summary is machine-generated.

A new resource provides extensive RNA-sequencing data for 12 non-human primate species, aiding genomic annotation and research into primate evolution, immunity, and pharmacology.

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Area of Science:

  • Genomics
  • Transcriptomics
  • Bioinformatics

Background:

  • RNA-sequencing (RNA-Seq) reveals extensive non-coding RNA functionality.
  • Uniform RNA-Seq data resources are lacking, especially for non-human primates (NHPs).

Purpose of the Study:

  • To establish a comprehensive RNA-Seq data and analysis infrastructure for NHPs.
  • To support NHP genome annotation and facilitate research in primate biology.

Main Methods:

  • Collected and processed RNA-Seq data from 12 NHP species.
  • Developed the NHP Reference Transcriptome Resource (http://nhprtr.org).
  • Provided early data access and browsable genome alignments.

Main Results:

  • The resource currently hosts data from 12 primate species, expanding to 15.
  • Data includes raw, cleaned, and processed RNA-Seq information.
  • Browsable alignments against the human genome are available via UCSC Genome Browser.

Conclusions:

  • The NHP Reference Transcriptome Resource is a valuable asset for NHP research.
  • It will advance studies in primate evolution, reproduction, infection, immunity, and pharmacology.