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Updated: May 16, 2026
06:30
A Non-Coding Small RNA MicC Contributes to Virulence in Outer Membrane Proteins in Salmonella Enteritidis
Published on: January 27, 2021
BSRD: a repository for bacterial small regulatory RNA
Lei Li1, Dandan Huang, Man Kit Cheung
1Biology Programme, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
Nucleic Acids Research
|December 4, 2012
Summary
Bacterial small regulatory non-coding RNAs (sRNAs) are crucial regulators. The new BSRD database offers a comprehensive resource for bacterial sRNAs, including annotations and RNA-Seq analysis tools.
Area of Science:
- Microbiology
- Molecular Biology
- Bioinformatics
Background:
- Small regulatory non-coding RNAs (sRNAs) are abundant bacterial post-transcriptional regulators.
- sRNAs regulate diverse cellular processes like quorum sensing, stress response, and metabolism.
- Current databases lack comprehensive bacterial sRNA data and analysis tools.
Purpose of the Study:
- To develop a comprehensive database for bacterial sRNAs.
- To provide annotations and expression profiles for bacterial sRNAs.
- To integrate RNA-Seq analysis tools for sRNA characterization.
Main Methods:
- Development of the Bacterial sRNAs Database (BSRD).
- Inclusion of published bacterial sRNA sequences and annotations.
- Implementation of a novel RNA-Seq analysis platform, sRNADeep.
Main Results:
- BSRD hosts over nine times more experimentally validated sRNAs than existing databases.
- The database includes combinatorial regulatory networks of transcription factors and sRNAs.
- sRNADeep facilitates sRNA characterization in large-scale transcriptome projects.
Conclusions:
- BSRD is a valuable, comprehensive resource for bacterial sRNA research.
- The integrated sRNADeep platform enhances the analysis of bacterial sRNAs.
- BSRD will be regularly updated to include new findings.
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