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Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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The BioGRID interaction database: 2013 update.

Andrew Chatr-Aryamontri¹, Bobby-Joe Breitkreutz, Sven Heinicke

¹Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Quebec, Canada H3C 3J7.

Nucleic Acids Research

|December 4, 2012

Summary

This summary is machine-generated.

The Biological General Repository for Interaction Datasets (BioGRID) archives over 500,000 genetic and protein interactions from scientific literature across 30+ model organisms. This open-access resource facilitates biological research through curated data and bioinformatics tools.

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Area of Science:

Molecular Biology
Bioinformatics
Genomics

Background:

The Biological General Repository for Interaction Datasets (BioGRID) is a vital open-access resource.
It archives curated genetic and protein interactions from the primary biomedical literature.
Data spans all major model organism species.

Purpose of the Study:

To provide a comprehensive, manually annotated archive of molecular interactions.
To support research across various model organisms and biomedical research areas.
To facilitate data sharing and integration with other major biological databases.

Main Methods:

Manual curation of genetic and protein interactions from published literature.
Complete literature curation for key model organisms like yeast and Arabidopsis thaliana.
Collaboration with model organism databases and engagement with text-mining communities.

Main Results:

As of September 2012, BioGRID contains over 500,000 manually annotated interactions.
Covers more than 30 model organisms with complete curation for Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Arabidopsis thaliana.
Established data sharing collaborations with major model organism databases.

Conclusions:

BioGRID serves as a central, freely accessible repository for interaction data.
The resource supports biological discovery through curated data and integrated bioinformatics tools.
Ongoing curation and collaborations ensure BioGRID remains a valuable asset for the research community.