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Lactic dehydrogenase: a biochemical marker for preeclampsia-eclampsia
S P Jaiswar1, Amrit Gupta, Rekha Sachan
1Department of Obstetrics and Gynecology, Queen Mary Hospital, CSMMU, Lucknow, UP India.
High serum Lactic Dehydrogenase (LDH) levels indicate more severe preeclampsia and eclampsia. Elevated LDH correlates with increased blood pressure and adverse maternal and perinatal outcomes.
Area of Science:
- Obstetrics and Gynecology
- Pathology
- Biochemistry
Background:
- Preeclampsia and eclampsia are serious hypertensive disorders of pregnancy.
- Biomarkers are needed to assess disease severity and predict outcomes.
Purpose of the Study:
- To investigate the correlation between serum Lactic Dehydrogenase (LDH) levels and the severity of preeclampsia and eclampsia.
- To assess the relationship between serum LDH levels and maternal and perinatal outcomes.
Main Methods:
- A prospective comparative study involving 146 pregnant women was conducted.
- Participants included normal pregnant women, mild preeclampsia, severe preeclampsia, and eclampsia groups.
- Statistical analysis utilized Chi-square, ANOVA, and sample t-tests.
Main Results:
- Serum LDH levels were significantly elevated in patients with preeclampsia and eclampsia (P < 0.001).
- Higher LDH levels showed a significant correlation with increased blood pressure (P < 0.10).
- Elevated LDH was associated with poorer maternal and perinatal outcomes.
Conclusions:
- Serum LDH is a valuable indicator of preeclampsia and eclampsia severity.
- High serum LDH levels correlate with adverse maternal and perinatal outcomes in these conditions.
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