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Meta-analysis of the expression of the mitosis-related gene Fam83D
1Department of Biology, Faculty of Science, Harran University, Osmanbey Campus, Sanliurfa, Turkey.
Abstract:
The family with sequence similarity 83, member D (Fam83D) encodes a mitotic spindle-associated protein. Its knockdown results in shorter spindles that fail to organize a correct metaphase plate. In this study, we demonstrated that Fam83D is coexpressed with well-known mitotic genes. Pathway analysis results also showed that cell cycle- and mitosis-related pathways are enriched with Fam83D-coexpressed genes. Furthermore, Fam83D is differentially expressed in various types of cancers. The results presented in this study suggest that Fam83D may be an important molecule for mitotic progression and equal segregation of chromosomes. Since the molecules that are involved in these mechanisms are crucial for mitosis as well as carcinogenesis, Fam83D should be considered as a novel regulator of mitosis and a putative carcinogenesis-related gene.
Insights
Family with sequence similarity 83, member D (Fam83D) is a mitotic spindle protein. Fam83D regulates cell division and chromosome segregation, suggesting its role in cancer development.
Area of Science:
- Cell Biology
- Molecular Biology
- Genetics
Background:
- The family with sequence similarity 83, member D (Fam83D) protein is associated with the mitotic spindle.
- Fam83D knockdown leads to defects in spindle organization and chromosome alignment.
Purpose of the Study:
- To investigate the role of Fam83D in mitotic progression.
- To explore the association of Fam83D with cell cycle and cancer-related pathways.
Main Methods:
- Gene coexpression analysis to identify Fam83D-associated genes.
- Pathway enrichment analysis to determine biological processes involving Fam83D.
- Analysis of Fam83D expression in cancer datasets.
Main Results:
- Fam83D is coexpressed with known mitotic genes.
- Cell cycle and mitosis pathways are significantly enriched with Fam83D-coexpressed genes.
- Fam83D exhibits differential expression across various cancer types.
Conclusions:
- Fam83D plays a crucial role in mitotic progression and chromosome segregation.
- Fam83D is a potential regulator of mitosis and a candidate gene involved in carcinogenesis.
