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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

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Published on: May 26, 2021

Breast cancer manifested by hematologic disorders.

Takashi Ishikawa¹, Daisuke Shimizu, Ayako Kito

¹Department of Breast and Thyroid Surgery Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama 232-0024, Japan;

Journal of Thoracic Disease

|December 4, 2012

Summary

This case study details a rare instance of breast cancer presenting as a hematologic disorder. Sequential chemotherapy demonstrated varied effectiveness against metastatic tumors in different organs.

Keywords:

Breast cancer disseminated intravascular coagulation multiple organ metastases

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Area of Science:

Oncology
Hematology

Background:

Breast cancer is a prevalent malignancy in women, but rarely presents with hematologic disorders.
Disseminated intravascular coagulation (DIC) is a critical condition characterized by widespread blood clotting and bleeding.

Observation:

A 35-year-old woman presented with DIC, later diagnosed with breast cancer.
The patient experienced pulmonary dysfunction (lymphangitis carcinomatosa) and liver dysfunction with jaundice during treatment.
Metastatic lesions were found in the bone marrow, lungs, and liver.

Findings:

Initial treatment with paclitaxel controlled DIC but was followed by pulmonary dysfunction.
Sequential chemotherapy with epirubicin, cyclophosphamide, and vinorelbine showed differential efficacy against various metastatic sites.
Despite treatment, the patient ultimately succumbed to liver failure.

Implications:

This case highlights the unusual presentation of breast cancer with hematologic manifestations.
It underscores the importance of considering diverse treatment strategies for metastatic breast cancer with organ-specific responses.
The study emphasizes the varied sensitivities of metastatic tumors to different chemotherapeutic agents.