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Related Experiment Video

Updated: May 16, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Low-dose Gamma Knife surgery for nonfunctioning pituitary adenomas.

Amr M N El-Shehaby1, Wael A Reda, Sameh R Tawadros

  • 1Gamma Knife Center Cairo, Nasser Institute, Shobra, Egypt.

Journal of Neurosurgery
|December 5, 2012
PubMed
Summary

A lower dose of 12 Gy Gamma Knife surgery for pituitary adenomas effectively controlled tumors and preserved pituitary function. This treatment also led to vision improvements in most patients with pre-existing visual field defects.

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Endocrinology

Background:

  • Gamma Knife surgery for pituitary adenomas aims to preserve vision and pituitary function while controlling tumor growth.
  • Higher radiation doses often correlate with increased post-surgery hormone deficiencies.
  • The study investigates a lower prescribed radiation dose for nonfunctioning pituitary adenomas.

Purpose of the Study:

  • To evaluate the feasibility of a lower prescribed radiation dose (12 Gy) for treating nonfunctioning pituitary adenomas.
  • To assess the impact of this lower dose on vision, pituitary function, and tumor growth control.
  • To determine if a reduced radiation dose can achieve tumor control without inducing pituitary dysfunction.

Main Methods:

  • Retrospective analysis of 38 patients with nonfunctioning pituitary adenomas treated between 2002 and 2008.

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  • Twenty-one patients with a mean follow-up of 44 months were analyzed.
  • All patients received a prescribed radiation dose of 12 Gy, with the visual pathway dose kept below 10 Gy.

    • Main Results:

    • Tumor size decreased in 52% of patients and remained stable in 43%.
    • Among patients with pre-existing visual field defects, 75% experienced improvement, with vision stabilizing in the rest.
    • No new pituitary dysfunction was observed; hormone profiles remained normal in all patients except those with pre-existing issues.

    Conclusions:

    • A 12-Gy prescribed dose appears sufficient for tumor control in nonfunctioning pituitary adenomas.
    • This lower dose effectively spares patients from radiation-induced pituitary dysfunction.
    • The treatment demonstrated potential for visual improvement, though larger studies are needed.