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Updated: May 16, 2026

Measuring Psoriasis Severity at Home
Published on: March 1, 2024
Inverse correlation between caveolin-1 expression and clinical severity in psoriasis vulgaris
1Department of Dermatology, Qilu Hospital, Shandong University, Jinan, China.
Objective:
This study investigated the clinical significance of expression of caveolin-1--a plasma membrane protein involved in caveola formation, endocytosis, signal transduction and angiogenesis--in the pathogenesis of psoriasis vulgaris.
Methods:
A total of 20 patients with psoriasis vulgaris and 20 healthy volunteers were recruited. The expressions of caveolin-1, Ki-67 (marker of cell proliferation) and CD34 (marker of angiogenesis) in skin biopsies were detected by immunohistochemistry, and the level of caveolin-1 protein was quantified by Western blotting. Clinical severity was assessed using the Psoriasis Area and Severity Index (PASI) score. Correlations between caveolin-1 expression and psoriasis severity, cell proliferation and angiogenesis were analysed using the Spearman rank correlation test.
Results:
Expression of caveolin-1 was significantly lower in psoriasis samples than in healthy skin samples. In psoriasis lesions, the level of caveolin-1 expression was inversely correlated with the severity of psoriasis, cell proliferation and angiogenesis.
Conclusions:
The level of caveolin-1 expression seems to be related to the clinical severity of psoriasis, and may play a role in the abnormal keratinocyte hyperplasia and angiogenesis seen in this condition.
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