Related Experiment Video

Updated: May 16, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Increased serum interleukin-34 in patients with coronary artery disease

Zhenglong Li1, Daoqun Jin, Yongbo Wu

  • 1Department of Cardiology, Central Hospital of Huangshi, Huangshi, Hubei Province, China.

The Journal of International Medical Research
|December 5, 2012
PubMed

Insights

Interleukin-34 (IL-34) levels are elevated in coronary artery disease (CAD) patients and correlate with high-sensitivity C-reactive protein (hs-CRP). IL-34 may serve as an independent predictor for CAD.

Area of Science:

  • Cardiology
  • Immunology
  • Biochemistry

Background:

  • Coronary artery disease (CAD) is a significant global health concern.
  • Interleukin-34 (IL-34) is a proinflammatory cytokine implicated in various inflammatory conditions.

Purpose of the Study:

  • To investigate serum levels of IL-34 in patients with CAD.
  • To determine the correlation between IL-34 and hs-CRP in CAD patients.
  • To assess IL-34 as a potential independent predictor of CAD.

Main Methods:

  • 91 patients underwent coronary angiography and were categorized into CAD (stenosis ≥ 50%) and control (< 50%) groups.
  • Serum IL-34 and hs-CRP levels were measured using standardized assays.
  • Multiple regression analysis was employed to identify independent predictors.

Main Results:

  • CAD patients exhibited significantly higher serum IL-34 (191.3 ± 17.9 pg/ml) and hs-CRP (3.08 ± 1.81 mg/ml) levels compared to controls.
  • A significant positive correlation was observed between IL-34 and hs-CRP in the CAD group.
  • IL-34 (OR 2.073) and hs-CRP (OR 1.878) were identified as independent predictors of CAD.

Conclusions:

  • Serum IL-34 levels are significantly elevated in patients diagnosed with coronary artery disease.
  • IL-34 levels show a positive correlation with hs-CRP, a known inflammation marker.
  • These findings suggest IL-34 may represent a novel independent biomarker for CAD.
Abstract

Related Concept Videos

Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...