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Related Experiment Videos

Preferences for opioids by the weight pulling method in rats.

T Suzuki1, Y Masukawa, T Kawai

  • 1Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.

Pharmacology, Biochemistry, and Behavior
|February 1, 1990
PubMed
Summary
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Rats pulled weights to obtain morphine or codeine, demonstrating drug-seeking behavior. The reinforcing effects of these opioids varied with treatment duration, with morphine showing a stronger effect than codeine.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Behavioral Science

Background:

  • Opioid drugs like morphine and codeine are frequently misused.
  • Understanding the reinforcing properties of opioids is crucial for addiction research.

Purpose of the Study:

  • To quantitatively evaluate the reinforcing effects of morphine and codeine in rats.
  • To investigate how treatment duration influences drug-seeking behavior.

Main Methods:

  • Developed a weight-pulling apparatus to measure the motivation for drug intake.
  • Utilized a choice/forced trial paradigm with drug-admixed food.
  • Administered morphine and codeine to rats before testing.

Main Results:

  • Rats exhibited drug-seeking behavior, pulling weight to access morphine and codeine.

Related Experiment Videos

  • The reinforcing efficacy of both drugs was dependent on the duration of prior drug exposure.
  • Morphine demonstrated a stronger reinforcing effect compared to codeine.

    • Conclusions:

    • The weight-pulling method provides a quantitative assessment of opioid reinforcing effects.
    • Opioid reinforcement is modulated by treatment history.
    • Findings contribute to understanding opioid addiction mechanisms.