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Related Experiment Video

Updated: May 16, 2026

Whole Mount Immunofluorescent Staining of the Neonatal Mouse Retina to Investigate Angiogenesis In vivo
08:47

Whole Mount Immunofluorescent Staining of the Neonatal Mouse Retina to Investigate Angiogenesis In vivo

Published on: July 9, 2013

Norrin expression in endothelial cells in the developing mouse retina.

Hanjae Lee1, Dong Hyun Jo, Jin Hyoung Kim

  • 1Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.

Acta Histochemica
|December 5, 2012
PubMed
Summary

Norrin protein is expressed by endothelial cells in developing retinas, crucial for retinal vascularization. This finding highlights Norrin

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Area of Science:

  • Ophthalmology
  • Developmental Biology
  • Cell Biology

Background:

  • Norrin protein, acting via the Frizzled-4 receptor and Wnt-signaling pathway, is vital for angiogenesis.
  • Norrin plays a critical role in retinal vascularization, essential for normal vision.

Purpose of the Study:

  • To investigate the expression pattern and cellular source of Norrin in the developing retina.
  • To understand Norrin's contribution to retinal vascular development and endothelial cell maintenance.

Main Methods:

  • Immunohistochemical analysis of Norrin protein expression in developing mouse and human retinas.
  • Localization of Norrin expression to specific cell types within retinal vasculature.

Main Results:

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Related Experiment Videos

Last Updated: May 16, 2026

Whole Mount Immunofluorescent Staining of the Neonatal Mouse Retina to Investigate Angiogenesis In vivo
08:47

Whole Mount Immunofluorescent Staining of the Neonatal Mouse Retina to Investigate Angiogenesis In vivo

Published on: July 9, 2013

Assessment and Characterization of Hyaloid Vessels in Mice
08:22

Assessment and Characterization of Hyaloid Vessels in Mice

Published on: May 15, 2019

Isolation of Murine Retinal Endothelial Cells for Next-Generation Sequencing
09:59

Isolation of Murine Retinal Endothelial Cells for Next-Generation Sequencing

Published on: October 11, 2021

  • Norrin protein expression was detected along retinal blood vessels in developing mouse retinas.
  • Norrin expression in mice coincided with vascular growth patterns and originated from endothelial cells of retinal capillaries.
  • Norrin was also found on endothelial cells in the developing human retina.

    • Conclusions:

    • Norrin is expressed by endothelial cells in both developing mouse and human retinas.
    • The findings suggest Norrin's involvement in intrinsic self-generative and protective mechanisms of developing retinal endothelial cells.
    • Norrin is crucial for the development and maintenance of ocular capillaries.