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Related Experiment Video

Updated: May 16, 2026

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

Optic nerve disease and axon pathophysiology.

Alireza Ghaffarieh1, Leonard A Levin

  • 1Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

International Review of Neurobiology
|December 5, 2012
PubMed
Summary

Optic neuropathy, a leading cause of blindness, involves retinal ganglion cell axon injury. Therapies like axoprotection aim to preserve axonal function after damage.

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An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival
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Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
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An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival
09:07

An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival

Published on: April 25, 2011

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Pathology

Background:

  • Optic neuropathy is a primary cause of irreversible blindness globally.
  • Glaucoma is the most frequent type, but other conditions like multiple sclerosis and giant cell arteritis also cause optic neuropathy.
  • Pathogenesis typically involves retinal ganglion cell axon injury, leading to degeneration.

Purpose of the Study:

  • To review clinical and pathophysiological aspects of common optic neuropathies.
  • To discuss recent advancements in understanding axonal degeneration.
  • To provide an update on therapeutic strategies for optic nerve diseases.

Main Methods:

  • Literature review of clinical and pathophysiological properties.
  • Synthesis of recent research findings on axonal degeneration.
  • Overview of current and emerging therapies for optic nerve disorders.

Main Results:

  • Detailed examination of three prevalent forms of optic neuropathy.
  • Insights into the mechanisms underlying axonal degeneration in optic neuropathies.
  • Current status of therapeutic interventions, including axoprotection.

Conclusions:

  • Optic neuropathies share common pathways of axonal injury and degeneration.
  • Axoprotection represents a promising therapeutic strategy for preserving vision.
  • Further research is crucial for developing effective treatments for optic nerve diseases.