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Updated: May 16, 2026

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
Published on: October 10, 2020
Glutathione transporters.
Anand K Bachhawat1, Anil Thakur, Jaspreet Kaur
1Indian Institute of Science Education & Research, Punjab, India. anand@iisermohali.ac.in
Glutathione transporters move this vital molecule within cells and out. While some transporters are identified, many remain unknown, hindering our understanding of cellular redox balance.
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Biology
Background:
- Glutathione (GSH) is essential in cytoplasm, organelles, and extracellular space.
- GSH transport across membranes is known, but transporter identity is often unclear.
- Understanding GSH transport is key to cellular redox homeostasis.
Purpose of the Study:
- To review current knowledge of glutathione transporters.
- To highlight characterized transporters and discuss others with supporting evidence.
- To identify gaps in understanding GSH transporter function and identity.
Main Methods:
- Review of existing literature on glutathione transporters.
- Focus on characterized yeast and mammalian transporters.
- Discussion of transporters with direct and indirect evidence.
Main Results:
- Molecular identity of a few GSH transporters is established.
- Yeast high-affinity and mammalian MRP proteins are well-characterized.
- Many suggested transporters lack direct evidence for transport activity.
Conclusions:
- Identifying remaining GSH transporters is crucial.
- Further research is needed to confirm transporter function.
- Structure-function insights from high-affinity transporters are valuable.
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