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Related Experiment Video

Updated: May 16, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Immune tolerance and transplantation.

Onder Alpdogan1, Marcel R M van den Brink

  • 1Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. onder.alpdogan@jefferson.edu

Seminars in Oncology
|December 5, 2012
PubMed
Summary
This summary is machine-generated.

Achieving immune tolerance is crucial for successful transplantation. Strategies like adoptive immunotherapy and mixed chimerism induction show promise in preventing rejection and graft-versus-host disease (GVHD).

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Area of Science:

  • Immunology
  • Transplantation Science

Background:

  • Successful transplantation (HSCT, solid organ) necessitates immune tolerance to allogeneic antigens.
  • T lymphocytes are key mediators of allograft rejection, graft failure, and graft-versus-host disease (GVHD).
  • Immune tolerance is established centrally (thymic T-cell depletion) and peripherally (suppression/elimination of mature T cells).

Purpose of the Study:

  • To review mechanisms of T-cell tolerance in transplantation.
  • To explore novel immunotherapies for inducing transplant tolerance.
  • To identify effective strategies for improving transplantation outcomes.

Main Methods:

  • Review of central and peripheral T-cell tolerance mechanisms.
  • Evaluation of adoptive immunotherapy using immune suppressor cells (Tregs, NK-T cells, veto cells, facilitating cells).
  • Analysis of mixed chimerism induction strategies (thymic irradiation, T-cell depletion, costimulatory blockade, alloreactive T-cell elimination).

Main Results:

  • Induction of transplant tolerance significantly improves transplantation outcomes.
  • Adoptive immunotherapy with immune suppressor cells offers a promising therapeutic approach.
  • Mixed chimerism induction, via combined methods, demonstrates effectiveness in establishing tolerance.

Conclusions:

  • Understanding T-cell tolerance mechanisms is vital for advancing transplantation.
  • Targeted immunotherapies and chimerism induction are key to successful allogeneic transplantation.
  • These strategies hold potential for reducing rejection and GVHD, enhancing graft survival.