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Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
Published on: August 10, 2017
Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors
Yanyang Li1, Yan Zhou, Pengyu Qian
1The General Hospital of Chinese People's Liberation Army, Beijing 100853, China.
Bioorganic & Medicinal Chemistry Letters
|December 5, 2012
Abstract:
A series of novel benzamides derivatives was designed and synthesized as HDAC inhibitors. Exploration of the structure-activity relationships resulted in compounds that are potent in vitro. In addition, the best compound 1a exhibited an acceptable pharmacokinetic profile with bioavailability in rat of 81% and could be considered as a candidate compound for further development.

