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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
Pharmaceutical cocrystals and poorly soluble drugs
Ranjit Thakuria1, Amit Delori, William Jones
1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
International Journal of Pharmaceutics
|December 5, 2012
Summary
Pharmaceutical cocrystal formation enhances solubility and bioavailability for poorly soluble drugs. Crystal engineering principles guide coformer selection for improved drug delivery and stability.
Area of Science:
- Materials Science
- Pharmaceutical Science
- Chemical Engineering
Background:
- Poorly soluble drugs present significant challenges in pharmaceutical development, limiting their therapeutic efficacy.
- Cocrystal formation has gained traction as a strategy to overcome these solubility and bioavailability limitations.
Purpose of the Study:
- To review the success of pharmaceutical cocrystals in improving solubility and dissolution rates of poorly soluble drugs.
- To elucidate the role of crystal engineering in selecting coformers and understanding supramolecular synthons.
- To summarize current knowledge on cocrystal structure-solubility relationships and thermodynamic stability.
Main Methods:
- Literature review of existing pharmaceutical cocrystal studies.
- Analysis of crystal engineering principles applied to coformer selection.
- Examination of supramolecular synthon characteristics in cocrystal structures.
Main Results:
- Numerous examples demonstrate improved solubility and dissolution rates of poorly soluble drugs via cocrystal formation.
- Evidence of enhanced animal pharmacokinetic data is presented for several cocrystal systems.
- Key factors influencing cocrystal thermodynamic stability and solubility are identified.
Conclusions:
- Cocrystal formation is a proven strategy for enhancing the performance of poorly soluble drugs.
- Crystal engineering provides a rational basis for designing effective cocrystals.
- Understanding structure-property relationships is crucial for optimizing cocrystal design.
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