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Painting proteins blue: β-(1-azulenyl)-L-alanine as a probe for studying protein-protein interactions
Yurii S Moroz1, Wolfgang Binder, Patrik Nygren
1Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY 13244, USA.
Chemical Communications (Cambridge, England)
|December 5, 2012
Abstract:
We demonstrated that β-(1-azulenyl)-L-alanine, a fluorescent pseudoisosteric analog of tryptophan, exhibits weak environmental dependence and thus allows for using weak intrinsic quenchers, such as methionines, to monitor protein-protein interactions while not perturbing them.
