Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Balancing scalpel and family life: Gender gaps in a European cohort of plastic surgeons.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2026
Same author

Is there a need for postoperative monitoring after open carpal tunnel release under WALANT?

Hand surgery & rehabilitation·2022
Same author

Expression of genes associated with nutrient uptake in intestines of chickens with different growth potentials show temporal changes but are not correlated with growth.

British poultry science·2021
Same author

Effects of mixed tocopherols added to milk replacer and calf starter on intake, growth, and indices of stress.

Journal of dairy science·2021
Same author

The effect of delayed feeding post-hatch on caeca development in broiler chickens.

British poultry science·2021
Same author

Peripheral histamine and neonatal growth performance in swine.

Domestic animal endocrinology·2019

Related Experiment Video

Updated: May 16, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Update on experimental acute pancreatitis.

S Kahl1, J M Mayer

  • 1Department of Internal Medicine, DRK Kliniken Berlin I Köpenick, Gastroenterology, Berlin, Germany. s.kahl@drk-kliniken-berlin.de

Minerva Gastroenterologica E Dietologica
|December 5, 2012
PubMed
Summary

Acute pancreatitis remains poorly understood due to challenges in observing early disease stages. This review details common experimental models for studying acute pancreatitis, outlining their respective benefits and drawbacks.

More Related Videos

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
07:10

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Related Experiment Videos

Last Updated: May 16, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
07:10

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Area of Science:

  • Gastroenterology
  • Pathophysiology
  • Experimental Medicine

Background:

  • Acute pancreatitis pathogenesis is not fully elucidated, hindering early diagnosis and intervention.
  • The disease presents with diverse etiologies and clinical trajectories, from mild to life-threatening.
  • Observing the initial pathophysiological events is challenging as patients seek medical attention after disease onset.

Purpose of the Study:

  • To review and compare commonly utilized experimental models for acute pancreatitis research.
  • To highlight the advantages and disadvantages of each model in the context of studying early disease mechanisms.

Main Methods:

  • Literature review of established experimental models for acute pancreatitis.
  • Comparative analysis of model systems based on their utility in investigating early pathophysiological events.
  • Discussion of model-specific advantages and limitations.

Main Results:

  • Several experimental models exist for acute pancreatitis research, each with unique strengths.
  • Models vary in their ability to replicate specific etiological factors and clinical presentations.
  • No single model perfectly recapitulates all aspects of human acute pancreatitis.

Conclusions:

  • Experimental models are crucial for advancing the understanding of acute pancreatitis.
  • Selection of an appropriate model is critical for successful research into early disease mechanisms.
  • Further development of refined models may improve insights into acute pancreatitis pathophysiology.