Related Experiment Video
Updated: May 16, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
Published on: May 30, 2025
Clinical value of serum 5-HT level in diagnosis and treatment of premature ejaculation
Changhai Yang1, Kunlong Tang, Baolong Wang
1Department of Urology, Tianjin Medical University General Hospital, Tianjin, China. YCH2836 @ 163.com
Objective:
To investigate serum 5-HT level in premature ejaculation (PE) patients and evaluate its clinical value in diagnosis and treatment of PE.
Methods:
71 patients were recruited in this study. Their serums were collected before and after sertraline treatment, while serums from 64 normal males were also collected as a control. Serum 5-HT level was detected by ELISA. SPSS 17.0 software was used to analyze the level of serum 5-HT and the ROC curve was drawn.
Results:
The average serum 5-HT level of PE patients was 61.9 ng/ml in our study, which was significantly lower than that of the control group (120.6 ng/ml), with statistical significance (p < 0.01). After sertraline treatment, the average serum 5-HT level in PE patients was 98.9 ng/ml, which was significantly higher than that before sertraline treatment. Sensitivity and specificity for serum 5-HT as a predictive diagnostic tool for PE were 92.2 and 93.0%, respectively, and the cutoff value of serum 5-HT was 86.4 ng/ml.
Conclusions:
Our study showed that serum 5-HT level may be used as a functional diagnostic tool for PE and an indicator in PE treatment.
Related Concept Videos
Male Sexual Response: Erection & Ejaculation
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
Psychosexual Stages of Personality: Genital