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Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Evolving spectrum of HIV-associated nephropathy
Salman Ahmed1, Luan Truong, Garabed Eknoyan
1Renal Section, Baylor College of Medicine, Houston, TX 77030, USA.
Nephron. Clinical Practice
|December 5, 2012
Summary
This study reports a rare association between diffuse infiltrative lymphocytosis syndrome (DILS) and multiple myeloma in two HIV patients presenting with kidney failure. This previously undocumented link highlights the evolving renal pathology in HIV/AIDS patients.
Area of Science:
- Nephrology
- Infectious Diseases
- Oncology
Background:
- The spectrum of kidney diseases in Human Immunodeficiency Virus (HIV) patients has shifted during the highly active antiretroviral therapy (HAART) era.
- There is a notable decrease in HIV-associated nephropathy (HIVAN) and a rise in non-HIVAN renal lesions.
Observation:
- Two cases of HIV-infected individuals with diffuse infiltrative lymphocytosis syndrome (DILS) and concurrent multiple myeloma are presented.
- Both patients, aged 23 and 54, experienced renal failure and proteinuria.
- Kidney biopsies confirmed DILS, with subsequent diagnoses of multiple myeloma in both.
Findings:
- Diffuse infiltrative lymphocytosis syndrome (DILS) is a rare, late complication of Acquired Immunodeficiency Syndrome (AIDS).
- The co-occurrence of DILS and multiple myeloma in HIV patients is a novel and previously unreported association.
- This association was observed in patients presenting with kidney failure, even without an AIDS-defining illness or other cancers.
Implications:
- Recognizing the association between HIV, DILS, and multiple myeloma is crucial for managing kidney failure in affected patients.
- This finding underscores the importance of comprehensive evaluation in HIV/AIDS patients with renal complications.
- The changing landscape of HIV-related renal pathology necessitates ongoing research and clinical vigilance.
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