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Updated: May 16, 2026

In vivo Interrogation of Central Nervous System Translatome by Polyribosome Fractionation
Published on: April 30, 2014
LncRNAs have a say in protein translation
1Regulation of Gene Expression Laboratory, Division of Oncology, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain. maitehuarte@unav.es
Abstract:
In a recent paper published in Nature, Carrieri et al. have identified in mouse a neuron-specific antisense lncRNA transcribed in the opposite strand of Uchl1 mRNA. Antisense Uchl1 specifically promotes the translation of UCHL1 under rapamycin treatment. To do so, the lncRNA only requires a SINEB2 repeat and a small region with sequence complementarity to the regulated mRNA.
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