Lessons from the heart and ischemic limbs: midkine as anti-inflammatory mediator for kidney diseases?
Related Experiment Video
Updated: May 16, 2026

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration
Published on: June 7, 2014
Delia Lidia Şalaru1, Peter R Mertens
1Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke-University Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany.
Abstract:
Inflammatory responses ensuing ischemia involve the release of numerous mediators. Among these the heparin-binding growth factor midkine has been recognized as a potent inducer of neoangiogenesis. In a recent publication, the release of midkine has been studied in different in vitro models, and effects of abrogated midkine expression by means of genetic knockout has been analyzed in ischemia models of the limbs. The observed effects indicate a profound effect exerted by midkine under ischemia in the coordination of the inflammatory response and neoangiogenesis.
Related Concept Videos
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury II: Pathophysiology
Acute Kidney Injury V: Interprofessional Care
Acute Kidney Injury I: Introduction
Chronic Kidney Disease III: Interprofessional Care
Acute Kidney Injury VI: Nursing Management
