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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Updated: May 16, 2026

Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy

Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy

Published on: July 9, 2016

Neuroimaging in mitochondrial disorders.

Andrea L Gropman¹

¹Department of Pediatrics and Neurology, Children's National Medical Center and the George Washington University of the Health Sciences, Washington, DC 20010, USA. agropman@childrensnational.org

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics

|December 5, 2012

Summary

This summary is machine-generated.

Mitochondrial disorders, caused by DNA mutations, disrupt energy production. Neuroimaging is crucial for diagnosing and monitoring these conditions in children, offering insights into neurological impact.

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Last Updated: May 16, 2026

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Area of Science:

Neurology
Genetics
Biochemistry

Background:

Mutations in nuclear or mitochondrial DNA disrupt oxidative phosphorylation, leading to mitochondrial dysfunction.
Mitochondrial disorders primarily affect the central and peripheral nervous systems, causing symptoms like seizures, intellectual disabilities, and stroke.
Diagnosing mitochondrial disorders can be challenging, especially in children, where established criteria are often adult-focused.

Purpose of the Study:

To review common neuroimaging patterns in pediatric mitochondrial disorders.
To explore the utility of advanced neuroimaging modalities in understanding mitochondrial dysfunction and its neurological consequences.
To highlight the diagnostic and prognostic value of neuroimaging in pediatric mitochondrial diseases.

Main Methods:

Review of existing literature on neuroimaging in mitochondrial disorders.
Analysis of common neuroimaging findings in affected children.
Discussion of emerging neuroimaging techniques and their potential applications.

Main Results:

Neuroimaging plays a significant role in the diagnosis and management of mitochondrial disorders in children.
Specific neuroimaging patterns are associated with different mitochondrial conditions.
Advanced imaging techniques offer potential for detailed insights into disease mechanisms and progression.

Conclusions:

Neuroimaging is a valuable tool for diagnosing and monitoring mitochondrial disorders in pediatric populations.
Understanding neuroimaging patterns aids in early detection and management, improving patient outcomes.
Further research utilizing advanced neuroimaging is needed to fully elucidate the impact of mitochondrial dysfunction on the nervous system.