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Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients

Metehan Yilman1, Cengiz Cokluk, Ahmet Baydin

  • 1Ondokuzmayis University, Faculty of Medicine, Department of Emergency, Samsun, Turkey.

Turkish Neurosurgery
|December 5, 2012
PubMed

Insights

Serum heart-type fatty acid binding protein (H-FABP) levels are elevated in patients with subarachnoid hemorrhage (SAH). Higher H-FABP levels correlate with increased SAH severity, but not ECG changes.

Area of Science:

  • Cardiology
  • Neurology
  • Biochemistry

Background:

  • Subarachnoid hemorrhage (SAH) can lead to cardiac complications.
  • Heart-type fatty acid binding protein (H-FABP) is a potential biomarker for cardiac injury.

Purpose of the Study:

  • To assess serum H-FABP levels in SAH patients.
  • To investigate the relationship between H-FABP and cardiac effects in SAH.
  • To explore correlations with SAH severity grading scales.

Main Methods:

  • Included 46 acute SAH patients and 20 healthy controls.
  • Performed 12-lead ECG on admission for all patients.
  • Measured serum H-FABP levels upon patient admission.

Main Results:

  • SAH patients exhibited significantly higher serum H-FABP levels than controls (p < 0.05).
  • No significant correlation was found between H-FABP levels and ECG changes.
  • Moderate positive correlation between H-FABP and Hunt and Hess grade (r=0.43, p < 0.05).
  • Weak positive correlation between H-FABP and Fisher radiological grade (r=0.38, p < 0.05).

Conclusions:

  • Serum H-FABP levels are elevated in patients with SAH.
  • Increased H-FABP levels are associated with higher SAH severity based on Hunt and Hess and Fisher classifications.
Abstract

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